Poly(ethylene glycol) 2-aMinoethyl ether acetic acid average Mn 3,500
NH2-PEG-COOH
CAS: 139729-28-5
Molecular Formula:
Poly(ethylene glycol) 2-aMinoethyl ether acetic acid average Mn 3,500 - Names and Identifiers
Poly(ethylene glycol) 2-aMinoethyl ether acetic acid average Mn 3,500 - Physico-chemical Properties
| Melting Point | 56-61°C |
| Flash Point | >176 °C |
| Appearance | solid |
| Storage Condition | -20°C |
Poly(ethylene glycol) 2-aMinoethyl ether acetic acid average Mn 3,500 - Risk and Safety
| WGK Germany | 3 |
Poly(ethylene glycol) 2-aMinoethyl ether acetic acid average Mn 3,500 - Introduction
NH2-PEG-COOH(NH2-PEG-COOH) is a compound in which an amino group is attached to one end of polyethylene glycol (PEG) and a carboxyl group is attached to the other end. It has the following properties:
1. Solubility: NH2-PEG-COOH has good solubility in water, making it easy to use in water-soluble systems.
2. Reactivity: Amino groups and carboxyl groups can be used for a variety of chemical reactions, such as esterification, amidation and coupling reactions.
The main uses of NH2-PEG-COOH include:
1. biomedical field: as a modifier of bioactive molecules, it can be used to modify proteins, peptides and drugs to improve their stability, water solubility and efficacy.
2. Drug delivery system: NH2-PEG-COOH can be used as a drug carrier material to fix the drug on the polyethylene glycol chain to achieve slow release and targeted delivery.
3. Surface modification: NH2-PEG-COOH can be used for surface modification materials, such as reducing naked eye observation and NF-κB signal inhibition.
The preparation method of the NH2-PEG-COOH includes the following steps:
1. polyethylene glycol is reacted with an activating reagent (such as 1-carboxyl -2,2,5,5-tetramethyl -1-phenolone acid) to generate an active ester or acid chloride.
2. react the active ester or acid chloride with an amination reagent (such as 1,3-diaminomethane) to generate amino-polyethylene glycol-acid chloride.
3. The amino-polyethylene glycol-acid chloride is reacted with a carbonate compound (such as chloroacetic acid or caprolactinoyl chloride) to generate amino-polyethylene glycol-carboxylic acid.
Regarding safety information, NH2-PEG-COOH belong to chemicals and need to be handled properly. During use, it is necessary to maintain good laboratory safety and avoid contact with skin, eyes and inhalation. If exposed, rinse immediately with plenty of water and seek medical assistance. Detailed safety instructions can be found in the material's Safety Data Sheet (SDS) or in the literature.
1. Solubility: NH2-PEG-COOH has good solubility in water, making it easy to use in water-soluble systems.
2. Reactivity: Amino groups and carboxyl groups can be used for a variety of chemical reactions, such as esterification, amidation and coupling reactions.
The main uses of NH2-PEG-COOH include:
1. biomedical field: as a modifier of bioactive molecules, it can be used to modify proteins, peptides and drugs to improve their stability, water solubility and efficacy.
2. Drug delivery system: NH2-PEG-COOH can be used as a drug carrier material to fix the drug on the polyethylene glycol chain to achieve slow release and targeted delivery.
3. Surface modification: NH2-PEG-COOH can be used for surface modification materials, such as reducing naked eye observation and NF-κB signal inhibition.
The preparation method of the NH2-PEG-COOH includes the following steps:
1. polyethylene glycol is reacted with an activating reagent (such as 1-carboxyl -2,2,5,5-tetramethyl -1-phenolone acid) to generate an active ester or acid chloride.
2. react the active ester or acid chloride with an amination reagent (such as 1,3-diaminomethane) to generate amino-polyethylene glycol-acid chloride.
3. The amino-polyethylene glycol-acid chloride is reacted with a carbonate compound (such as chloroacetic acid or caprolactinoyl chloride) to generate amino-polyethylene glycol-carboxylic acid.
Regarding safety information, NH2-PEG-COOH belong to chemicals and need to be handled properly. During use, it is necessary to maintain good laboratory safety and avoid contact with skin, eyes and inhalation. If exposed, rinse immediately with plenty of water and seek medical assistance. Detailed safety instructions can be found in the material's Safety Data Sheet (SDS) or in the literature.
Last Update：2024-04-09 21:21:28
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Multiple Specifications
Product Name: NH2-PEG-COOH Visit Supplier Webpage Request for quotationTel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
View History
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